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Neural mechanisms for flexible motor control
Neural mechanisms for flexible motor control
A Japanese proverb says, “柔能く剛を制す” (ju yoku go wo seisu), meaning that flexibility can overcome strength. One of the hallmarks of animal behavior is the ability to flexibly and appropriately adapt to ever-changing environments. To achieve such flexible behavior, animals must recognize the state of the environment and the body, predict future changes, understand behavioral goals, and generate appropriate motor commands.
Optimal feedback control theory provides a unifying framework for understanding these complex and diverse sensorimotor processes. Our research aims to elucidate the neural mechanisms underlying voluntary motor control and movement disorders within this theoretical framework. To this end, we combine cortical and subcortical neural recordings in non-human primates, analyses of the dynamical structure of neural activity, muscle activity recordings, computational simulations, and artificial neural network modeling.
Takei T, Lomber SG, Cook DJ, Scott SH (2021) Transient deactivation of dorsal premotor cortex or parietal area 5 impairs feedback control of the limb in macaques. Current Biology 31(7):1476–1487.
Selected publications [+]
Takei T, Lomber SG, Cook DJ, Scott SH (2021) Transient deactivation of dorsal premotor cortex or parietal area 5 impairs feedback control of the limb in macaques. Current Biology 31(7):1476–1487.
Takei T, Crevecoeur F, Herter TM, Cross KP, Scott SH (2018) Correlations Between Primary Motor Cortex Activity with Recent Past and Future Limb Motion During Unperturbed Reaching. Journal of Neuroscience 38:7787–7799.
Scott SH, Cluff T, Lowrey CR, Takei T (2015) Feedback control during voluntary motor actions. Current Opinions in Neurobiology 33, 85–94. [review]
武井 智彦 (2023) 未来を予測して身体運動の時間遅れを克服する神経メカニズム. Clinical Neuroscience 41(8), 1036-1039 [review, in Japanese]
井澤淳, 武井智彦 (2022) 確率論的最適フィードバック制御の脳内機構. 計測と制御 61:309–315. [review, in Japanese]
武井智彦 (2021) 動作の遅れを克服する予測のしくみ. 体育の科学. [review, in Japanese]
Neural mechanisms for dexterous hand movements
Neural mechanisms for dexterous hand movements
Dexterous hand movements are a highly developed motor function in primates and are fundamental to our everyday and cultural activities. Multiple evolutionarily distinct neural pathways contribute to the control of these movements, but their functional differences remain unclear. By electrophysiologically recording neuronal activity related to hand movements from the spinal cord, brainstem, and cerebral cortex of non-human primates during grasping tasks, we aim to identify the physiological and anatomical properties of these pathways. These findings will help reveal the neural basis for the evolution of skilled hand movements in primates and the mechanisms of functional recovery after injury to the central nervous system.
Song Y, Hirashima M, Takei T (2022) Neural network models for spinal implementation of muscle synergies. Frontiers in System Neuroscience 16:800628.
Selected publications [+]
Takei T, Oya T, Seki K (2026) Primate dexterous hand movements are controlled by functionally distinct premotoneuronal systems. Science Advances 12:eaea1184.
Song Y, Hirashima M, Takei T (2022) Neural network models for spinal implementation of muscle synergies. Frontiers in System Neuroscience 16:800628.
Oya T, Takei T, Seki K (2020) Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip. Communications Biology 3:156.
Takei T, Confais J, Tomatsu S, Oya T, Seki K (2017) Neural basis for hand muscle synergies in the primate spinal cord. Proceedings of the National Academy of Sciences of USA 114, 8643–8648.
Takei T, Seki K (2013a) Spinal Premotor Interneurons Mediate Dynamic and Static Motor Commands for Precision Grip in Monkeys. Journal of Neuroscience 33:8850–8860.
Takei T, Seki K (2013b) Synaptic and functional linkages between spinal premotor interneurons and hand-muscle activity during precision grip. Frontiers in Computational Neuroscience 7:40.
Takei T, Seki K (2010) Spinal Interneurons Facilitate Coactivation of Hand Muscles during a Precision Grip Task in Monkeys. Journal of Neuroscience 30:17041–17050.
Takei T, Seki K (2008) Spinomuscular Coherence in Monkeys Performing a Precision Grip Task. Journal of Neurophysiology 99:2012–2020.
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